MUPCDH

Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene.^[5][6][7]

CDHR5
Identifiers
Aliases	CDHR5, MU-PCDH, MUCDHL, MUPCDH, MLPCDH, cadherin related family member 5
External IDs	OMIM: 606839; MGI: 1919290; HomoloGene: 69345; GeneCards: CDHR5; OMA:CDHR5 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 616,577 bp[1] End 626,078 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,848,996 bp[2] End 140,856,699 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum mucosa of transverse colon rectum right lobe of liver human kidney testicle epithelium of colon gallbladder sural nerve appendix Top expressed in duodenum large intestine colon right kidney jejunum crypt of lieberkuhn of small intestine ileum left colon human kidney proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding beta-catenin binding protein binding cell adhesion molecule binding Cellular component integral component of membrane spanning component of plasma membrane brush border membrane clathrin-coated pit plasma membrane extracellular exosome membrane cell projection microvillus membrane apical plasma membrane Biological process cell adhesion regulation of microvillus length homophilic cell adhesion via plasma membrane adhesion molecules intermicrovillar adhesion cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53841 72040 Ensembl ENSG00000099834 ENSG00000273572 ENSMUSG00000025497 UniProt Q9HBB8 Q8VHF2 RefSeq (mRNA) NM_001171968 NM_017717 NM_021924 NM_031264 NM_031265 NM_001114322 NM_028069 RefSeq (protein) NP_001165439 NP_068743 NP_112554 NP_001107794 NP_082345 Location (UCSC) Chr 11: 0.62 – 0.63 Mb Chr 7: 140.85 – 140.86 Mb PubMed search [3] [4]
Wikidata
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This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternative splicing has been identified, with observed variation resulting in the presence or absence of domains. In addition, splicing occurs in the 5' UTR but transcripts including these variations have not been described completely.^[7]