MXD1

Not to be confused with Mothers against decapentaplegic.

MAD protein is a protein that in humans is encoded by the MXD1 gene.^[5][6]

MXD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E91, 1G1E, 1NLW, 1PD7, 1S5Q
Identifiers
Aliases	MXD1, BHLHC58, MAD, MAD1, MAX dimerization protein 1
External IDs	OMIM: 600021; MGI: 96908; HomoloGene: 1767; GeneCards: MXD1; OMA:MXD1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 69,897,688 bp[1] End 69,942,945 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 37.75 cM Start 86,624,024 bp[2] End 86,646,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell mucosa of pharynx oocyte secondary oocyte amniotic fluid blood oral cavity jejunal mucosa mucosa of colon mucosa of sigmoid colon Top expressed in granulocyte left colon blood retinal pigment epithelium duodenum ciliary body secondary oocyte epithelium of stomach jejunum conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding transcription coregulator activity protein dimerization activity transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm mitochondrion cytosol Biological process multicellular organism development cell population proliferation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4084 17119 Ensembl ENSG00000059728 ENSMUSG00000001156 UniProt Q05195 P50538 RefSeq (mRNA) NM_002357 NM_001202513 NM_001202514 NM_010751 RefSeq (protein) NP_001189442 NP_001189443 NP_002348 n/a Location (UCSC) Chr 2: 69.9 – 69.94 Mb Chr 6: 86.62 – 86.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function as an activator) and is a candidate tumor suppressor.^[6]

Interactions

MXD1 has been shown to interact with Histone deacetylase 2,^[7][8] SMC3,^[9] MLX,^[10][11] SIN3A^[12][13][14] and MAX.^{[9][15][16][17]}