MXD4

Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.^[5][6]

MXD4
Identifiers
Aliases	MXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDs	MGI: 104991; HomoloGene: 4712; GeneCards: MXD4; OMA:MXD4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 2,247,432 bp[1] End 2,262,109 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B2|5 17.84 cM Start 34,331,227 bp[2] End 34,345,064 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior pituitary right lung apex of heart right adrenal cortex Descending thoracic aorta tibial nerve ascending aorta right coronary artery right lobe of thyroid gland Top expressed in ascending aorta aortic valve Paneth cell fossa Rostral migratory stream left lung lobe calvaria vestibular sensory epithelium thymus vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding protein dimerization activity transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10608 17122 Ensembl ENSG00000123933 ENSMUSG00000037235 UniProt Q14582 Q60948 RefSeq (mRNA) NM_006454 NM_010753 RefSeq (protein) NP_006445 n/a Location (UCSC) Chr 4: 2.25 – 2.26 Mb Chr 5: 34.33 – 34.35 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.^[6]