MXRA5

Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.^[3]

MXRA5
Identifiers
Aliases	MXRA5, matrix remodeling associated 5
External IDs	OMIM: 300938; HomoloGene: 56704; GeneCards: MXRA5; OMA:MXRA5 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.33 Start 3,308,565 bp[1] End 3,346,652 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii hair follicle skin of hip urethra vulva pylorus cardia parietal pleura nipple human penis n/a More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function extracellular matrix structural constituent Cellular component extracellular exosome extracellular region collagen-containing extracellular matrix Biological process response to transforming growth factor beta Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25878 n/a Ensembl ENSG00000101825 n/a UniProt Q9NR99 n/a RefSeq (mRNA) NM_015419 n/a RefSeq (protein) NP_056234 n/a Location (UCSC) Chr X: 3.31 – 3.35 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.^[3]

Clinical relevance

Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.^[4]