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MYBL2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

MYBL2
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Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.[5]

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Function

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.[6] MYBL2 is deregulated in various cancer types and can contribute to cancer progression.[7][8]

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Interactions

MYBL2 has been shown to interact with:

References

Further reading

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