MYBL2

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.^[5]

MYBL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D9A
Identifiers
Aliases	MYBL2, B-MYB, BMYB, MYB proto-oncogene like 2
External IDs	OMIM: 601415; MGI: 101785; HomoloGene: 1847; GeneCards: MYBL2; OMA:MYBL2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 43,667,019 bp[1] End 43,716,495 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H2|2 84.0 cM Start 162,896,607 bp[2] End 162,926,608 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ganglionic eminence ventricular zone beta cell bone marrow bone marrow cells appendix mucosa of transverse colon lymph node trabecular bone Top expressed in zygote yolk sac secondary oocyte blastocyst primary oocyte morula epiblast female urethra tail of embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component Myb complex nucleoplasm nucleus Biological process regulation of cell cycle regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II cell differentiation mitotic spindle assembly regulation of transcription by RNA polymerase II positive regulation of neuron apoptotic process cellular response to leukemia inhibitory factor mitotic cell cycle positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4605 17865 Ensembl ENSG00000101057 ENSMUSG00000017861 UniProt P10244 P48972 RefSeq (mRNA) NM_002466 NM_001278610 NM_008652 RefSeq (protein) NP_001265539 NP_002457 NP_032678 Location (UCSC) Chr 20: 43.67 – 43.72 Mb Chr 2: 162.9 – 162.93 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.^[6] MYBL2 is deregulated in various cancer types and can contribute to cancer progression.^[7][8]

Interactions

MYBL2 has been shown to interact with:

• CDK9^[9]
• CREB-binding protein^[10]
• Cyclin A1^[11]
• Cyclin-dependent kinase inhibitor 1C^[12]
• EP300^[13]
• PARP1^[14]
• Retinoblastoma-like protein 1^[12][15]