MYCBP2

Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.^[5][6]

MYCBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GBW, 3HWJ
Identifiers
Aliases	MYCBP2, PAM, Myc-bp2, Phr, MYC binding protein 2, E3 ubiquitin protein ligase, PHR1, MYC binding protein 2
External IDs	OMIM: 610392; MGI: 2179432; HomoloGene: 9005; GeneCards: MYCBP2; OMA:MYCBP2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q22.3 Start 77,042,474 bp[1] End 77,327,094 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E2.3|14 51.79 cM Start 103,350,847 bp[2] End 103,584,250 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus hair follicle lateral nuclear group of thalamus Brodmann area 10 frontal pole cerebellar vermis nipple Pons pars compacta Top expressed in ventromedial nucleus anterior amygdaloid area medial geniculate nucleus lateral hypothalamus lateral septal nucleus paraventricular nucleus of hypothalamus mammillary body lateral geniculate nucleus ventral tegmental area medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding transferase activity guanyl-nucleotide exchange factor activity zinc ion binding protein homodimerization activity ubiquitin protein ligase activity Cellular component membrane nucleus cytoplasm cytoskeleton microtubule cytoskeleton axon cell projection intracellular membrane-bounded organelle Biological process regulation of transcription, DNA-templated protein ubiquitination transcription, DNA-templated motor neuron axon guidance branchiomotor neuron axon guidance central nervous system projection neuron axonogenesis regulation of protein localization negative regulation of protein catabolic process cell morphogenesis involved in neuron differentiation neuromuscular process regulation of cytoskeleton organization regulation of axon guidance positive regulation of protein ubiquitination circadian regulation of gene expression rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23077 105689 Ensembl ENSG00000005810 ENSMUSG00000033004 UniProt O75592 Q7TPH6 RefSeq (mRNA) NM_015057 NM_207215 RefSeq (protein) NP_055872 NP_997098 Location (UCSC) Chr 13: 77.04 – 77.33 Mb Chr 14: 103.35 – 103.58 Mb PubMed search [3] [4]
Wikidata
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Structure

PAM contains a N-terminal leucine zipper, central MYC-binding, and C-terminal histone-binding protein homology domains.^[5]

Interactions

MYCBP2 has been shown to interact with Myc.^[5]