MYL9

Myosin regulatory light polypeptide 9 is a protein that in humans is encoded by the MYL9 gene.^[5]

MYL9
Identifiers
Aliases	MYL9, LC20, MLC-2C, MLC2, MRLC1, MYRL2, myosin light chain 9, MMIHS4
External IDs	OMIM: 609905; MGI: 2138915; HomoloGene: 21230; GeneCards: MYL9; OMA:MYL9 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 36,541,497 bp[1] End 36,551,447 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,617,340 bp[2] End 156,623,578 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery thoracic aorta ascending aorta Descending thoracic aorta left coronary artery saphenous vein muscle layer of sigmoid colon apex of heart Top expressed in ascending aorta aortic valve tunica media of zone of aorta atrium cervix migratory enteric neural crest cell blood umbilical cord calvaria external carotid artery More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding structural constituent of muscle metal ion binding Cellular component myosin complex cytosol muscle myosin complex Biological process platelet aggregation regulation of muscle contraction muscle contraction regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10398 98932 Ensembl ENSG00000101335 ENSMUSG00000067818 UniProt P24844 Q9CQ19 RefSeq (mRNA) NM_181526 NM_006097 NM_172118 RefSeq (protein) NP_006088 NP_852667 NP_742116 Location (UCSC) Chr 20: 36.54 – 36.55 Mb Chr 2: 156.62 – 156.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene.^[6]