MYLK3

Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.^[5][6]

MYLK3
Identifiers
Aliases	MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDs	OMIM: 612147; MGI: 2443063; HomoloGene: 35278; GeneCards: MYLK3; OMA:MYLK3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q11.2 Start 46,702,282 bp[1] End 46,790,407 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 86,050,932 bp[2] End 86,112,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium right ventricle myocardium of left ventricle right auricle of heart Skeletal muscle tissue of biceps brachii body of tongue apex of heart thoracic diaphragm Skeletal muscle tissue of rectus abdominis triceps brachii muscle Top expressed in myocardium of ventricle atrium interventricular septum atrioventricular valve epithelium of small intestine esophagus migratory enteric neural crest cell endocardial cushion left ventricle bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function calmodulin-dependent protein kinase activity kinase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity ATP binding myosin light chain kinase activity Cellular component cytoplasm actin cytoskeleton cytosol intracellular anatomical structure Biological process protein phosphorylation positive regulation of sarcomere organization regulation of vascular permeability involved in acute inflammatory response sarcomere organization cellular response to interleukin-1 phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction sarcomerogenesis cardiac myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91807 213435 Ensembl ENSG00000140795 ENSMUSG00000031698 UniProt Q32MK0 Q3UIZ8 RefSeq (mRNA) NM_001308301 NM_182493 NM_001297612 NM_175441 RefSeq (protein) NP_001295230 NP_872299 NP_001284541 NP_780650 Location (UCSC) Chr 16: 46.7 – 46.79 Mb Chr 8: 86.05 – 86.11 Mb PubMed search [3] [4]
Wikidata
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Function

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.^[7]

See also

• Myosin light-chain kinase