MYO1C

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.^[5][6]

MYO1C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BYF
Identifiers
Aliases	MYO1C, MMI-beta, MMIb, NMI, myr2, myosin IC, MyoIC
External IDs	OMIM: 606538; MGI: 106612; HomoloGene: 32046; GeneCards: MYO1C; OMA:MYO1C - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.3 Start 1,464,186 bp[1] End 1,492,686 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 45.92 cM Start 75,541,330 bp[2] End 75,564,736 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung tibial nerve subcutaneous adipose tissue popliteal artery tibial arteries gastric mucosa buccal mucosa cell right coronary artery sural nerve abdominal fat Top expressed in right lung right lung lobe left lung submandibular gland lacrimal gland parotid gland tunica media of zone of aorta left lung lobe ascending aorta endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein C-terminus binding nucleotide binding actin binding signaling receptor binding cytoskeletal motor activity calmodulin binding ATP binding protein binding microfilament motor activity actin filament binding microtubule motor activity microtubule binding Cellular component extracellular exosome filamentous actin brush border nucleolus cytoplasm nuclear pore cell projection cytosol nucleus stress fiber stereocilium unconventional myosin complex microvillus basal plasma membrane membrane myosin I complex ruffle membrane raft plasma membrane myosin complex cytoplasmic vesicle stereocilium membrane lateral plasma membrane ruffle membrane nucleoplasm nuclear body stereocilium bundle cytoplasmic vesicle membrane phagocytic vesicle Biological process Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of protein targeting to membrane positive regulation of cell migration by vascular endothelial growth factor signaling pathway epigenetic maintenance of chromatin in transcription-competent conformation positive regulation of cell migration protein targeting regulation of bicellular tight junction assembly protein transport protein targeting to membrane mRNA transport positive regulation of vascular endothelial growth factor signaling pathway positive regulation of cellular response to insulin stimulus positive regulation of actin filament polymerization transport vesicle transport along actin filament cellular response to interferon-gamma microtubule-based movement Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4641 17913 Ensembl ENSG00000197879 ENSMUSG00000017774 UniProt O00159 Q9WTI7 RefSeq (mRNA) NM_033375 NM_001080779 NM_001080950 NM_001363855 NM_001080774 NM_001080775 NM_008659 NM_001370611 RefSeq (protein) NP_001074248 NP_001074419 NP_203693 NP_001350784 NP_001074243 NP_001074244 NP_032685 NP_001357540 Location (UCSC) Chr 17: 1.46 – 1.49 Mb Chr 11: 75.54 – 75.56 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19.^[6]