MYO1E

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.^[5][6]

MYO1E
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XMF
Identifiers
Aliases	MYO1E, FSGS6, HuncM-IC, MYO1C, myosin IE
External IDs	OMIM: 601479; MGI: 106621; HomoloGene: 55864; GeneCards: MYO1E; OMA:MYO1E - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.2 Start 59,132,434 bp[1] End 59,372,871 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 39.41 cM Start 70,114,632 bp[2] End 70,307,048 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve gallbladder tibial arteries rectum stromal cell of endometrium skin of leg Descending thoracic aorta mucosa of transverse colon ascending aorta Top expressed in lumbar spinal ganglion mesenteric lymph nodes calvaria left colon lip cumulus cell tail of embryo duodenum epithelium of stomach lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding actin filament binding microfilament motor activity protein binding phosphatidylinositol binding actin binding cytoskeletal motor activity ATP binding lipid binding Cellular component cytoplasm cell-cell junction clathrin-coated endocytic vesicle adherens junction cell junction brush border actin cytoskeleton extracellular exosome cytoskeleton cytoplasmic vesicle clathrin-coated vesicle myosin complex Biological process hemopoiesis endocytosis glomerular visceral epithelial cell development glomerular basement membrane development kidney development post-embryonic hemopoiesis in utero embryonic development actin filament-based movement vasculogenesis nitrogen compound metabolic process glomerular filtration platelet-derived growth factor receptor signaling pathway metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4643 71602 Ensembl ENSG00000157483 ENSMUSG00000032220 UniProt Q12965 E9Q634 RefSeq (mRNA) NM_004998 NM_181072 NM_025612 RefSeq (protein) NP_004989 NP_851417 Location (UCSC) Chr 15: 59.13 – 59.37 Mb Chr 9: 70.11 – 70.31 Mb PubMed search [3] [4]
Wikidata
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Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. ^[7]

The MYO1E gene was included in several genetic signatures for cancer prognosis.^[8]