KAT8

K(lysine) acetyltransferase 8 (KAT8) is an enzyme that in humans is encoded by the KAT8 gene.^[5][6]

KAT8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GIV, 2PQ8, 2Y0M, 3QAH, 3TOA, 3TOB, 4DNC
Identifiers
Aliases	KAT8, MOF, MYST1, ZC2HC8, hMOF, lysine acetyltransferase 8, LIGOWS
External IDs	OMIM: 609912; MGI: 1915023; HomoloGene: 41676; GeneCards: KAT8; OMA:KAT8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 31,114,489 bp[1] End 31,131,393 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F3|7 69.83 cM Start 127,511,688 bp[2] End 127,525,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right ovary left ovary corpus epididymis cerebellar vermis paraflocculus of cerebellum left uterine tube external globus pallidus apex of heart Top expressed in seminiferous tubule spermatocyte spermatid primary oocyte neural layer of retina hand muscle of thigh otolith organ tail of embryo utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity transcription factor binding metal ion binding histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity histone acetyltransferase activity (H4-K5 specific) methylated histone binding protein binding histone acetyltransferase activity (H4-K16 specific) enzyme binding acetyltransferase activity acyltransferase activity histone binding Cellular component nucleoplasm chromosome MLL1 complex histone acetyltransferase complex nucleus kinetochore MSL complex nuclear matrix Biological process myeloid cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated histone H4-K5 acetylation positive regulation of transcription, DNA-templated regulation of autophagy histone H4-K16 acetylation negative regulation of transcription, DNA-templated histone H4-K8 acetylation histone acetylation chromatin organization positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84148 67773 Ensembl ENSG00000103510 ENSMUSG00000030801 UniProt Q9H7Z6 Q9D1P2 RefSeq (mRNA) NM_032188 NM_182958 NM_026370 NM_001360699 RefSeq (protein) NP_115564 NP_892003 NP_080646 NP_001347628 Location (UCSC) Chr 16: 31.11 – 31.13 Mb Chr 7: 127.51 – 127.53 Mb PubMed search [3] [4]
Wikidata
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Function

The MYST family of histone acetyltransferases, which includes KAT8, was named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin.^[6]

KAT8 is also known as MOF, and in humans hMOF. Given its fundamental role in modulating higher-order chromatin structure, hMOF is involved in many of the steps of the DNA damage response.^[7] The human hMOF gene encodes an enzyme that specifically acetylates histone H4 at lysine 16.^[7][8] The depletion of hMOF greatly decreases DNA double-strand break repair by both non-homologous end joining and homologous recombination.^[8] Thus MOF activity is critical for double-strand break repair.^[8]

Interactions

KAT8 has been shown to interact with MORF4L1.^[9]