KAT7 (gene)

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene.^[5][6][7] It specifically acetylates H4 histones at the lysine12 residue (H4K12)^[8] and is necessary for origin licensing and DNA replication.^[9][10] KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1.^[11] Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.^[12]

KAT7
Identifiers
Aliases	KAT7, HBO1, HBOA, MYST2, ZC2HC7, lysine acetyltransferase 7
External IDs	OMIM: 609880; MGI: 2182799; HomoloGene: 5134; GeneCards: KAT7; OMA:KAT7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 49,788,648 bp[1] End 49,835,026 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 95,165,085 bp[2] End 95,201,072 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve testicle left testis Achilles tendon right testis ventricular zone gonad epithelium of colon popliteal artery tibial arteries Top expressed in spermatocyte ankle joint Rostral migratory stream zygote spermatid secondary oocyte seminiferous tubule tail of embryo cumulus cell granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA-binding transcription factor activity zinc ion binding metal ion binding histone acetyltransferase activity protein binding acyltransferase activity DNA replication origin binding DNA-binding transcription factor activity, RNA polymerase II-specific H4 histone acetyltransferase activity histone binding Cellular component nucleoplasm nucleolus histone acetyltransferase complex nucleus cytoplasm cytosol Biological process regulation of transcription, DNA-templated transcription, DNA-templated histone H4-K5 acetylation DNA replication histone H3 acetylation histone H4-K16 acetylation histone H4-K8 acetylation histone H4-K12 acetylation positive regulation of protein localization to nucleus stress-activated protein kinase signaling cascade positive regulation of transcription by RNA polymerase II response to sorbitol response to hydroxyurea response to actinomycin D response to dithiothreitol response to anisomycin positive regulation of histone H4 acetylation histone acetylation chromatin organization negative regulation of transcription, DNA-templated internal peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11143 217127 Ensembl ENSG00000136504 ENSMUSG00000038909 UniProt O95251 Q5SVQ0 RefSeq (mRNA) NM_001199155 NM_001199156 NM_001199157 NM_001199158 NM_007067 NM_001346706 NM_001195003 NM_001195004 NM_177619 RefSeq (protein) NP_001186084 NP_001186085 NP_001186086 NP_001186087 NP_001333635 NP_008998 NP_001181932 NP_001181933 NP_808287 NP_001392123 NP_001392124 NP_001392125 NP_001392126 NP_001392127 NP_001392128 NP_001392129 NP_001392130 NP_001392131 NP_001392132 NP_001392133 NP_001392134 NP_001392135 NP_001392136 NP_001392137 NP_001392138 NP_001392139 NP_001392140 NP_001392141 NP_001392142 NP_001392143 NP_001392144 NP_001392145 NP_001392146 NP_001392147 NP_001392148 NP_001392149 NP_001392150 NP_001392151 NP_001392152 NP_001392153 NP_001392154 NP_001392155 NP_001392156 Location (UCSC) Chr 17: 49.79 – 49.84 Mb Chr 11: 95.17 – 95.2 Mb PubMed search [3] [4]
Wikidata
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Interactions

KAT7 has been shown to interact with:

• AR,^[6]
• CDT1,^[12]
• MCM2^[13][5]
• ORC1L^[5] and
• VIM,^[14][15]