MCM2

"MCM-2" redirects here. For the warship, see USS Defender (MCM-2).

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.^[5][6]

MCM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UUZ, 5BNV, 5BNX, 5BO0, 5C3I, 5JA4
Identifiers
Aliases	MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70
External IDs	OMIM: 116945; MGI: 105380; HomoloGene: 3325; GeneCards: MCM2; OMA:MCM2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 127,598,410 bp[1] End 127,622,436 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 88,860,456 bp[2] End 88,875,762 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone embryo ganglionic eminence trabecular bone bone marrow cells gonad gingival epithelium appendix Top expressed in tibiofemoral joint mandibular prominence maxillary prominence epiblast tail of embryo somite primitive streak fetal liver hematopoietic progenitor cell ventricular zone genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding helicase activity histone binding metal ion binding DNA helicase activity protein binding enzyme binding DNA replication origin binding hydrolase activity ATP binding single-stranded DNA binding single-stranded DNA helicase activity 3'-5' DNA helicase activity Cellular component cytoplasm microtubule cytoskeleton nucleoplasm nuclear origin of replication recognition complex chromatin MCM complex nucleus cytosol nucleolus Biological process cellular response to interleukin-4 nucleosome assembly G1 phase DNA replication DNA replication initiation DNA unwinding involved in DNA replication apoptotic process cell cycle cochlea development G1/S transition of mitotic cell cycle negative regulation of DNA helicase activity double-strand break repair via break-induced replication pre-replicative complex assembly involved in nuclear cell cycle DNA replication mitotic DNA replication initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4171 17216 Ensembl ENSG00000073111 ENSMUSG00000002870 UniProt P49736 P97310 RefSeq (mRNA) NM_004526 NM_008564 RefSeq (protein) NP_004517 NP_032590 Location (UCSC) Chr 3: 127.6 – 127.62 Mb Chr 6: 88.86 – 88.88 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.^[7]

Interactions

MCM2 has been shown to interact with:

• AKAP8,^[8]
• Cell division cycle 7-related protein kinase,^[9]
• MCM3,^[9]
• MCM4,^{[9][10][11][12]}
• MCM5,^[9][13]
• MCM6,^{[9][10][11][14][15]}
• MCM7,^{[9][10][11][15][16]}
• ORC1L,^[9]
• ORC2L,^[9]
• ORC4L,^[9]
• ORC5L,^[9] and
• Replication protein A1.^[9]

See also

• Mini Chromosome Maintenance