Macrophage-capping protein

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.^[5][6][7]

CAPG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J72, 1JHW
Identifiers
Aliases	CAPG, AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like
External IDs	OMIM: 153615; MGI: 1098259; HomoloGene: 37523; GeneCards: CAPG; OMA:CAPG - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 85,394,753 bp[1] End 85,418,432 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C1 Start 72,521,374 bp[2] End 72,539,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte skin of abdomen left lobe of thyroid gland granulocyte right lobe of thyroid gland skin of leg upper lobe of left lung right lung ectocervix gums Top expressed in granulocyte corneal stroma lip decidua ankle joint conjunctival fornix esophagus stroma of bone marrow gastrula ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding actin binding protein binding protein domain specific binding cadherin binding actin filament binding Cellular component cytoplasm F-actin capping protein complex melanosome centriole mitotic spindle nucleolus extracellular exosome nucleus Flemming body nucleoplasm extracellular region ruffle lamellipodium cell projection Biological process barbed-end actin filament capping extracellular matrix disassembly positive regulation of podosome assembly actin filament capping protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 822 12332 Ensembl ENSG00000042493 ENSMUSG00000056737 UniProt P40121 P24452 RefSeq (mRNA) NM_001256139 NM_001256140 NM_001747 NM_001320732 NM_001320733 NM_001320734 NM_001042534 NM_001271395 NM_001271415 NM_007599 RefSeq (protein) NP_001243068 NP_001243069 NP_001307661 NP_001307662 NP_001307663 NP_001738 n/a Location (UCSC) Chr 2: 85.39 – 85.42 Mb Chr 6: 72.52 – 72.54 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins.^[8] The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively, spliced transcript variants have been observed, but have not been fully described.^[7]