Maneb

Maneb (manganese ethylene-bis-dithiocarbamate) is a fungicide and a polymeric complex of manganese with the ethylene bis (dithiocarbamate) anionic ligand.^[1]

Maneb

Names
IUPAC name [[2-[(Dithiocarboxy)amino]ethyl]carbamodithioato]](2-)-kS,kS']manganese
Other names Manganese ethylene-1,2-bisdithiocarbamate, polymer
Identifiers
CAS Number	12427-38-2 Y
3D model (JSmol)	Interactive image
ChemSpider	2297517 N
ECHA InfoCard	100.032.400
MeSH	Maneb
PubChem CID	3032581
UNII	K221E12G7T Y
CompTox Dashboard (EPA)	DTXSID9020794
InChI InChI=1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2 Key: YKSNLCVSTHTHJA-UHFFFAOYSA-L
SMILES [Mn+]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)S[Mn]SC(=S)NCCNC(=S)[S-]
Properties
Chemical formula	(C4H6MnN2S4)n
Appearance	Yellow to brown colored crystalline solid
Density	1.92 g/cm3
Melting point	192 to 204 °C (378 to 399 °F; 465 to 477 K) (decomposes)
Solubility in water	160 mg/L
Hazards
GHS labelling:
Pictograms
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Health effects

See also: Manganism, Parkinsonism, and Parkinson's disease

Exposure to maneb can occur when breathed in; it can irritate the eyes, nose, and throat as well as cause headache, fatigue, nervousness, dizziness, seizures and even unconsciousness. Prolonged or long-term exposure may interfere with the function of the thyroid. Exposure to maneb is also shown to induce a Parkinson's disease like neurotoxicity in mice.^[2] It is still challenged whether maneb, along with Paraquat, is an environmental risk factor for Parkinson's disease.^[3][4] In 2022 a review from India stated that "From the studies we can consider that PQ and MB with its combined effects has tremendous contribution towards neurodegeneration in PD."^[5]

Production

Manganese(II) ethylenebis(dithiocarbamate) of low ethylenethiourea (ETU) content is prepared by mixing disodium ethylenebis (dithiocarbamate) with formaldehyde in aqueous medium then mixing a water-soluble manganese(II) salt to precipitate the maneb. The product can be further formulated with a metal salt and also with paraformaldehyde. (See External links for the patent citation)

Applications

Maneb, is a broad spectrum fungicide that is extensively applied against a wide range of fungal pathogens affecting ornamental plants, food and feed crops. It can also be used to create a toxin-based animal model of Parkinson's disease, usually in primates.^[6][7]

Environmental effects

Regulation

Maneb was included in a pesticide ban proposed by the Swedish Chemicals Agency^[8] and approved by the European Parliament on January 13, 2009.^[9]

See also

• Metam sodium - A related dithiocarbamate salt which is also used as a fungicide.
• Zineb - ethylene bis(dithiocarbamate) with zinc instead of manganese.
• Mancozeb - A common fungicide containing Zineb and Maneb.