Metabotropic glutamate receptor 8

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.^[5][6]

GRM8
Identifiers
Aliases	GRM8, GLUR8, GPRC1H, MGLUR8, mGlu8, glutamate metabotropic receptor 8
External IDs	OMIM: 601116; MGI: 1351345; HomoloGene: 654; GeneCards: GRM8; OMA:GRM8 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.33 Start 126,438,598 bp[1] End 127,253,093 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.1- A3.2 Start 27,275,118 bp[2] End 28,135,177 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle left testis right testis oocyte Epithelium of choroid plexus prefrontal cortex Brodmann area 9 corpus callosum cingulate gyrus Top expressed in ganglion cell layer secondary oocyte zygote inner nuclear layer superior frontal gyrus embryo primary visual cortex embryo outer nuclear layer dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function glutamate receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane integral component of plasma membrane presynaptic membrane membrane plasma membrane Biological process adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway signal transduction visual perception response to stimulus regulation of synaptic transmission, glutamatergic G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled glutamate receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2918 14823 Ensembl ENSG00000179603 ENSMUSG00000024211 UniProt O00222 P47743 RefSeq (mRNA) NM_000845 NM_001127323 NM_001371083 NM_001371084 NM_001371085 NM_001371086 NM_001371087 NM_001371088 NM_008174 NM_001311072 NM_001361125 RefSeq (protein) NP_000836 NP_001120795 NP_001358012 NP_001358013 NP_001358014 NP_001358015 NP_001358016 NP_001358017 NP_001298001 NP_032200 NP_001348054 Location (UCSC) Chr 7: 126.44 – 127.25 Mb Chr 6: 27.28 – 28.14 Mb PubMed search [3] [4]
Wikidata
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Function

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.^[6]

Ligands

• (S)-3,4-DCPG: agonist^[7]
• AZ12216052: positive allosteric modulator^[8]

See also

• Metabotropic glutamate receptor