Mexedrone

Mexedrone (also known as 4-MMC-MeO) is a stimulant and an entactogen drug of the cathinone class that has been sold online as a designer drug.^[1][2][3][4] It is the alpha-methoxy derivative of Mephedrone.

Mexedrone

Legal status
Legal status	DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act Illegal in Japan and Sweden
Identifiers
IUPAC name 3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one
CAS Number	2166915-02-0 Y
PubChem CID	129318262
ChemSpider	52324347
UNII	2AFZ6G3X7J
Chemical and physical data
Formula	C12H17NO2
Molar mass	207.273 g·mol−1
3D model (JSmol)	Interactive image
SMILES Cc1ccc(cc1)C(=O)C(COC)NC
InChI InChI=1S/C12H17NO2/c1-9-4-6-10(7-5-9)12(14)11(13-2)8-15-3/h4-7,11,13H,8H2,1-3H3 Key:JHGDCSPZKQLBOP-UHFFFAOYSA-N

Pharmacology

Mexedrone acts as a weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC₅₀ values of 5,289 nM, 8,869 nM, and 6,844 nM, respectively, as well as a weak serotonin releasing agent (SRA) with an EC₅₀ value of 2,525 nM.^[5]

Legal status

Mexedrone is illegal in Sweden as of January 26, 2016^[6] as well as Japan as of August 24, 2016.^[7]

See also

• 4-Methylcathinone
• 4-Methylbuphedrone
• 4-Methylethcathinone
• Zylofuramine