MiR-144

miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.^[1] In humans, miR-144 has been characterised as a "common miRNA signature"^[2] of a number of different tumours.

miR-144
Conserved secondary structure of miR-144 precursor microRNA
Identifiers
Symbol	miR-144
Alt. Symbols	MIR144
Rfam	RF00682
miRBase	MI0000460
miRBase family	MIPF0000093
NCBI Gene	406936
HGNC	31531
OMIM	612070
RefSeq	NR_029685
Other data
RNA type	miRNA
Domain	Mammalia
GO	0035195
SO	0001244
Locus	Chr. 17 q11.2
PDB structures	PDBe

GATA4 is thought to activate transcription of the miR-144 microRNA precursor.^[3]

Function

miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.^[4] One of the identified targets of miR-144 is insulin receptor substrate 1.^[5]

Applications

miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.^[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.^[3]