Mibampator

Mibampator (developmental code name LY-451395) is a positive allosteric modulator (PAM) of the AMPA receptor (AMPAR), an ionotropic glutamate receptor, which was under development by Eli Lilly for the treatment of agitation/aggression in Alzheimer's disease but was never marketed.^[1][2] It reached phase II clinical trials prior to the discontinuation of its development.^[1]

Mibampator

Clinical data
Other names	LY-451395
Identifiers
IUPAC name N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
CAS Number	375345-95-2
PubChem CID	9889366
ChemSpider	8065037
UNII	A9V5BW73UU
KEGG	D09931
ChEMBL	ChEMBL1277001
CompTox Dashboard (EPA)	DTXSID20190977
Chemical and physical data
Formula	C21H30N2O4S2
Molar mass	438.60 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H](CNS(=O)(=O)C(C)C)C1=CC=C(C=C1)C2=CC=C(C=C2)CCNS(=O)(=O)C
InChI InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1 Key:ULRDYYKSPCRXAJ-KRWDZBQOSA-N

Mibampator belongs to the biarylpropylsulfonamide group of AMPAR PAMs, which also includes LY-404187, LY-503430, and PF-04958242 among others.^[3] It is a "high-impact" AMPAR potentiator, unlike "low-impact" AMPAR potentiators from other classes like CX-516 and its congener farampator (CX-691, ORG-24448), and is able to elicit comparatively more robust increases in AMPAR signaling.^[2] In animals, high-impact AMPAR potentiators enhance cognition and memory at low doses, but produce motor coordination disruptions, convulsions, and neurotoxicity at higher doses.^[4]

Mibampator failed to produce cognitive improvement in patients with Alzheimer's disease, though it did show improvements in neuropsychiatric measures.^[5] A caveat of the study was that the maximally tolerated dosage of the drug could not be used due to toxicity, and dosages in the same range in rodents notably failed to improve memory-related behavior.^[6]

See also

• AMPA receptor positive allosteric modulator
• List of investigational aggression drugs