MicC RNA

The MicC non-coding RNA (previously known as IS063 ^[1]) is located between the ompN and ydbK genes in E. coli. This Hfq-associated RNA is thought to be a regulator of the expression level of the OmpC porin protein, with a 5′ region of 22 nucleotides potentially forming an antisense interaction with the ompC mRNA. Along with MicF RNA this family may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli.^[2] The expression of micC was shown to be increased in the presence of beta-lactam antibiotics.^[3]

MicC RNA
Predicted secondary structure and sequence conservation of MicC
Identifiers
Symbol	MicC
Alt. Symbols	IS063
Rfam	RF00121
Other data
RNA type	Gene; sRNA
Domain(s)	Bacteria
SO	SO:0000655
PDB structures	PDBe

See also

• Two-component regulatory system