MicroRNA 375

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene. ^[3]

MIR375
Identifiers
Aliases	MIR375, MIRN375, hsa-mir-375, miRNA375, mir-375, microRNA 375
External IDs	OMIM: 611173; GeneCards: MIR375; OMA:MIR375 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,001,645 bp[1] End 219,001,708 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans blood right frontal lobe monocyte placenta stomach muscle layer of sigmoid colon transverse colon right lobe of thyroid gland minor salivary glands n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 494324 n/a Ensembl ENSG00000198973 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 2: 219 – 219 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzymes to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].