MicroRNA 486-1

MicroRNA 486-1 is a functional RNA that in humans is encoded by the MIR486-1 gene. ^[3]

MIR486-1
Identifiers
Aliases	MIR486-1, MIR486, MIRN486, hsa-mir-486, hsa-mir-486-1, mir-486-1, microRNA 486-1
External IDs	GeneCards: MIR486-1; OMA:MIR486-1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 41,660,441 bp[1] End 41,660,508 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skeletal muscle tissue apex of heart bone marrow right hemisphere of cerebellum muscle of leg gastrocnemius muscle gonad left ventricle lymph node right auricle n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 619554 n/a Ensembl ENSG00000274705 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 8: 41.66 – 41.66 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.