Mir-145

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.^[3]

MIR145
Identifiers
Aliases	MIR145, microRNA 145, MIRN145, miR-145, miRNA145, MIRN145 microRNA, human
External IDs	OMIM: 611795; GeneCards: MIR145; OMA:MIR145 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 149,430,646 bp[1] End 149,430,733 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery gastric mucosa smooth muscle tissue left uterine tube tibial arteries muscle layer of sigmoid colon body of uterus myometrium left coronary artery prostate n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406937 n/a Ensembl ENSG00000276365 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 5: 149.43 – 149.43 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

mir-145
Conserved secondary structure of mir-145
Identifiers
Symbol	mir-145
Rfam	RF00675
miRBase family	MIPF0000079
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

Targets

MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule JAM-A as well as the actin bundling protein fascin in breast cancer and endometriosis cells, resulting in a reduction of cell motility.^[4][5] Larsson et al.^[6] showed that miR-145 targets the 3' UTR of the FLI1 gene, a finding that was later supported by Zhang et al.^[7]

Role in cancer

miR-145 is hypothesised to be a tumor suppressor.^[8] miR-145 has been shown to be down-regulated in breast cancer.^[5] miR-145 is also involved in colon cancer^[7][9][10] and acute myeloid leukemia.^[11]