Mitogen-activated protein kinase kinase kinase 6

Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. ^[5]

MAP3K6
Identifiers
Aliases	MAP3K6, ASK2, MAPKKK6, MEKK6, mitogen-activated protein kinase kinase kinase 6
External IDs	OMIM: 604468; MGI: 1855691; HomoloGene: 3435; GeneCards: MAP3K6; OMA:MAP3K6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 27,354,067 bp[1] End 27,366,961 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 132,968,129 bp[2] End 132,980,240 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung skin of abdomen skin of leg apex of heart ectocervix upper lobe of left lung left uterine tube tibial nerve canal of the cervix gastric mucosa Top expressed in primary oocyte zygote secondary oocyte superior surface of tongue corneal stroma hair follicle lip umbilical cord muscle of thigh esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity ATP binding magnesium ion binding metal ion binding kinase activity Cellular component intracellular anatomical structure Biological process protein phosphorylation phosphorylation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9064 53608 Ensembl ENSG00000142733 ENSMUSG00000028862 UniProt O95382 Q9WTR2 RefSeq (mRNA) NM_001297609 NM_004672 NM_145319 NM_016693 RefSeq (protein) NP_001284538 NP_004663 NP_057902 Location (UCSC) Chr 1: 27.35 – 27.37 Mb Chr 4: 132.97 – 132.98 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].