Modafiendz

Modafiendz, also known as N-methyl-4,4-difluoromodafinil or as N-methylbisfluoromodafinil, is a wakefulness-promoting agent related to modafinil that was never marketed.^[1][2][3] It is sold online and used non-medically as a nootropic (cognitive enhancer).^[1][2][3]

Modafiendz

Clinical data
Other names	N-Methyl-4,4-difluoromodafinil; Methyldifluoromodafinil; N-Methylbisfluoromodafinil; Bisfluoro-N-methylmodafinil; Methylflmodafinil
Identifiers
IUPAC name 2-[bis(4-fluorophenyl)methylsulfinyl]-N-methylacetamide
CAS Number	1613222-54-0
PubChem CID	132989661
ChemSpider	58951582
UNII	223VWC34TA
Chemical and physical data
Formula	C16H15F2NO2S
Molar mass	323.36 g·mol−1
3D model (JSmol)	Interactive image
SMILES CNC(=O)CS(=O)C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F
InChI InChI=1S/C16H15F2NO2S/c1-19-15(20)10-22(21)16(11-2-6-13(17)7-3-11)12-4-8-14(18)9-5-12/h2-9,16H,10H2,1H3,(H,19,20) Key:MQZWTCIUDSDFCQ-UHFFFAOYSA-N

Modafiendz is the bis-fluoro and N-methylated derivative of modafinil as well as the N-methyl analogue of flmodafinil (CRL-40,940; bisfluoromodafinil) and fladrafinil (CRL-40,941; bisfluoroadrafinil).^[1][2]

Modafinil and its analogues have been found to act as selective dopamine reuptake inhibitors and this is thought to be involved in their wakefulness-promoting effects.^[2]

See also

• List of modafinil analogues and derivatives