Motile sperm domain containing 2

Motile sperm domain containing 2 is a protein that in humans is encoded by the MOSPD2 gene.^[5] It is an endoplasmic reticulum–resident protein involved in membrane contact site formation.^[6] Its domain homologous to Major Sperm Protein (MSP domain) is very similar to VAPA/VAPB, so it has been described as the third human member of the VAP protein family.

MOSPD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WIC
Identifiers
Aliases	MOSPD2, Motile sperm domain containing 2
External IDs	MGI: 1924013; HomoloGene: 22125; GeneCards: MOSPD2; OMA:MOSPD2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp22.2 Start 14,873,421 bp[1] End 14,922,327 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X F5 Start 163,719,165 bp[2] End 163,763,371 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte corpus callosum inferior ganglion of vagus nerve monocyte C1 segment subthalamic nucleus visceral pleura blood decidua pons Top expressed in parotid gland Epithelium of choroid plexus carotid body ciliary body sciatic nerve iris left lung lobe conjunctival fornix seminal vesicula calvaria More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 158747 76763 Ensembl ENSG00000130150 ENSMUSG00000061778 UniProt Q8NHP6 Q9CWP6 RefSeq (mRNA) NM_001177475 NM_152581 NM_001330241 NM_001290523 NM_001290524 NM_029730 RefSeq (protein) NP_001170946 NP_001317170 NP_689794 NP_001277452 NP_001277453 NP_084006 Location (UCSC) Chr X: 14.87 – 14.92 Mb Chr X: 163.72 – 163.76 Mb PubMed search [3] [4]
Wikidata
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