Mucin 5AC

Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.^[5][6][7]

MUC5AC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 5AJN, 5AJP, 5AJO
Identifiers
Aliases	MUC5AC, MUC5, TBM, leB, mucin, mucin 5AC, oligomeric mucus/gel-forming
External IDs	OMIM: 158373; MGI: 104697; HomoloGene: 137237; GeneCards: MUC5AC; OMA:MUC5AC - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 1,157,953 bp[1] End 1,201,138 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 87.23 cM Start 141,342,709 bp[2] End 141,372,968 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa gastric mucosa body of stomach fundus gallbladder canal of the cervix islet of Langerhans appendix urinary bladder muscle tissue Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach conjunctival fornix duodenum olfactory epithelium quadriceps femoris muscle esophagus cornea pancreas More reference expression data BioGPS n/a
Gene ontology Molecular function extracellular matrix structural constituent Cellular component cytoplasm Golgi lumen extracellular region extracellular exosome extracellular space plasma membrane mucus layer Biological process phosphatidylinositol-mediated signaling O-glycan processing stimulatory C-type lectin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4586 17833 Ensembl ENSG00000215182 ENSG00000283158 ENSMUSG00000037974 UniProt P98088 n/a RefSeq (mRNA) NM_017511 NM_001304359 NM_010844 RefSeq (protein) NP_001291288 n/a Location (UCSC) Chr 11: 1.16 – 1.2 Mb Chr 7: 141.34 – 141.37 Mb PubMed search [3] [4]
Wikidata
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MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,^[8] and has also been associated with greater protection against influenza infection.^[9]

Clinical relevance

This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).^[10]