Multisynthetase complex auxiliary component p38

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.^[5][6][7]

AIMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DPG, 4YCU, 4YCW, 5A34, 5A1N, 5A5H
Identifiers
Aliases	AIMP2, JTV-1, JTV1, P38, PRO0992, Multisynthetase complex auxiliary component p38, aminoacyl tRNA synthetase complex interacting multifunctional protein 2, HLD17
External IDs	OMIM: 600859; MGI: 2385237; HomoloGene: 4594; GeneCards: AIMP2; OMA:AIMP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 6,009,255 bp[1] End 6,023,834 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 143,839,522 bp[2] End 143,846,665 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte tibialis anterior muscle vastus lateralis muscle deltoid muscle body of tongue muscle of arm biceps brachii gastrocnemius muscle triceps brachii muscle Top expressed in triceps brachii muscle quadriceps femoris muscle vastus lateralis muscle sternocleidomastoid muscle gastrocnemius muscle extensor digitorum longus muscle plantaris muscle temporal muscle medial head of gastrocnemius muscle tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular adaptor activity Cellular component cytoplasm membrane nucleus cytosol aminoacyl-tRNA synthetase multienzyme complex Biological process multicellular organism development cell differentiation type II pneumocyte differentiation positive regulation of neuron death positive regulation of protein ubiquitination tRNA aminoacylation for protein translation protein biosynthesis negative regulation of cell population proliferation apoptotic process positive regulation of aminoacyl-tRNA ligase activity protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7965 231872 Ensembl ENSG00000106305 ENSMUSG00000029610 UniProt Q13155 Q8R010 RefSeq (mRNA) NM_006303 NM_001326606 NM_001326607 NM_001326609 NM_001326611 NM_018570 NM_001326610 NM_001362785 NM_001362787 NM_001172146 NM_146165 RefSeq (protein) NP_001313535 NP_001313536 NP_001313538 NP_001313539 NP_001313540 NP_006294 NP_001349714 NP_001349716 NP_001165617 NP_666277 Location (UCSC) Chr 7: 6.01 – 6.02 Mb Chr 5: 143.84 – 143.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.^[7]

Interactions

Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin (ligase),^[8] P53^[6] and KARS.^[9][10]