Musashi-1

RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.^[5][6]

MSI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UAW, 2MSS, 2MST, 2RS2
Identifiers
Aliases	MSI1, musashi RNA binding protein 1
External IDs	OMIM: 603328; MGI: 107376; HomoloGene: 55657; GeneCards: MSI1; OMA:MSI1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 120,341,330 bp[1] End 120,369,164 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,567,658 bp[2] End 115,593,757 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence frontal pole left testis right testis anterior pituitary islet of Langerhans amygdala cingulate gyrus anterior cingulate cortex Top expressed in neural layer of retina ventricular zone molar epithelium of lens Rostral migratory stream ganglionic eminence tail of embryo habenula epiblast somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function single-stranded RNA binding nucleic acid binding poly(U) RNA binding identical protein binding RNA binding Cellular component cytoplasm polysome nucleus ribonucleoprotein complex Biological process nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4440 17690 Ensembl ENSG00000135097 ENSMUSG00000054256 UniProt O43347 Q61474 RefSeq (mRNA) NM_002442 NM_008629 NM_001376960 NM_001376961 NM_001376962 NM_001376963 RefSeq (protein) NP_002433 NP_032655 NP_001363889 NP_001363890 NP_001363891 NP_001363892 Location (UCSC) Chr 12: 120.34 – 120.37 Mb Chr 5: 115.57 – 115.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation.^[7][6]

Clinical significance

Over expression of this gene is associated with the grade of the malignancy and proliferative activity in gliomas and melanomas.^[7] An increased expression of MSI1 protein is observed in endometriosis and endometrial carcinoma^[8] siRNA-mediated inhibition of MSI expression in endometrial carcinoma cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway^[9]

MSI1 is highly expressed in neural progenitor cells and is required for normal development of the brain. A mutation in these gene is responsible for autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome and may explain why these cells are highly susceptible to Zika virus infection.^[10][11]

See also

• Musashi-2