N-myc-interactor

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.^[5][6][7]

NMI
Identifiers
Aliases	NMI, N-myc and STAT interactor
External IDs	OMIM: 603525; MGI: 1928368; HomoloGene: 3441; GeneCards: NMI; OMA:NMI - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.3 Start 151,270,470 bp[1] End 151,289,894 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 51,838,499 bp[2] End 51,863,506 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte trabecular bone blood bone marrow palpebral conjunctiva epithelium of nasopharynx parietal pleura tendon of biceps brachii germinal epithelium Top expressed in jejunum mucous cell of stomach duodenum ileum granulocyte right lung lobe thymus seminal vesicula spleen left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transcription coregulator activity identical protein binding Cellular component cytoplasm nucleoplasm cytosol Biological process transcription by RNA polymerase II interferon-gamma-mediated signaling pathway regulation of nucleic acid-templated transcription positive regulation of protein K48-linked ubiquitination receptor signaling pathway via JAK-STAT negative regulation of type I interferon production inflammatory response negative regulation of innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9111 64685 Ensembl ENSG00000123609 ENSMUSG00000026946 UniProt Q13287 O35309 RefSeq (mRNA) NM_004688 NM_001141948 NM_001141949 NM_019401 RefSeq (protein) NP_004679 NP_001135420 NP_001135421 NP_062274 Location (UCSC) Chr 2: 151.27 – 151.29 Mb Chr 2: 51.84 – 51.86 Mb PubMed search [3] [4]
Wikidata
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Function

NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.^[7]

Interactions

NMI (gene) has been shown to interact with BRCA1,^[8] IFI35,^[9] Myc,^[8] and STAT5A,^[6] and TUBA3C.^[10]