Glycylpeptide N-tetradecanoyltransferase 1

Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an enzyme that in humans is encoded by the NMT1 gene.^[5][6] It belongs to the protein N-terminal methyltransferase and glycylpeptide N-tetradecanoyltransferase family of enzymes. This enzyme can be inhibited by NMT inhibitors.

NMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RXT, 3IU1, 3IU2, 3IWE, 3JTK, 4C2Y, 4C2Z
Identifiers
Aliases	NMT1, Nmt1, AW536594, NMT, N-myristoyltransferase 1
External IDs	OMIM: 160993; MGI: 102579; HomoloGene: 69027; GeneCards: NMT1; OMA:NMT1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,957,992 bp[1] End 45,109,016 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 102,919,016 bp[2] End 102,959,738 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right adrenal gland islet of Langerhans sural nerve gastrocnemius muscle left adrenal gland right adrenal cortex Achilles tendon left adrenal cortex granulocyte Top expressed in Ileal epithelium endothelial cell of lymphatic vessel vestibular membrane of cochlear duct Paneth cell primitive streak lacrimal gland gastrula decidua interventricular septum hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity glycylpeptide N-tetradecanoyltransferase activity myristoyltransferase activity Cellular component membrane plasma membrane extrinsic component of membrane cytoplasm mitochondrion cytosol Biological process regulation of rhodopsin mediated signaling pathway in utero embryonic development positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway N-terminal peptidyl-glycine N-myristoylation N-terminal protein myristoylation cellular ketone metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4836 18107 Ensembl ENSG00000136448 ENSMUSG00000020936 UniProt P30419 O70310 RefSeq (mRNA) NM_021079 NM_008707 RefSeq (protein) NP_066565 NP_032733 Location (UCSC) Chr 17: 44.96 – 45.11 Mb Chr 11: 102.92 – 102.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse