N6AMT1

N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene. ^[5]

N6AMT1
Identifiers
Aliases	N6AMT1, C21orf127, HEMK2, MTQ2, N6AMT, m.HsaHemK2P, PRED28, N-6 adenine-specific DNA methyltransferase 1 (putative), N-6 adenine-specific DNA methyltransferase 1, PrmC, KMT9
External IDs	OMIM: 614553; MGI: 1915018; HomoloGene: 5637; GeneCards: N6AMT1; OMA:N6AMT1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 28,872,191 bp[1] End 28,885,371 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C3.3 Start 87,151,073 bp[2] End 87,165,630 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad ventricular zone right uterine tube apex of heart left ovary right adrenal gland right adrenal cortex ganglionic eminence body of uterus Top expressed in interventricular septum superior cervical ganglion hand genital tubercle yolk sac right kidney spinal ganglia Rostral migratory stream tail of embryo proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding methyltransferase activity protein methyltransferase activity transferase activity protein binding S-adenosylmethionine-dependent methyltransferase activity Cellular component cytosol cytoplasm protein-containing complex Biological process positive regulation of cell growth protein methylation methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29104 67768 Ensembl ENSG00000156239 ENSMUSG00000044442 UniProt Q9Y5N5 Q6SKR2 RefSeq (mRNA) NM_013240 NM_182749 NM_001159331 NM_026366 RefSeq (protein) NP_037372 NP_877426 NP_001152803 NP_080642 Location (UCSC) Chr 21: 28.87 – 28.89 Mb Chr 16: 87.15 – 87.17 Mb PubMed search [3] [4]
Wikidata
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Function

The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]. N6AMT1 functions as a protein glutamine methyltransferase and is essential for mouse development (Liu et al., Mol. Cell. Biol. 2010).