NANS

For other uses, see Nans.

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.^[5][6]

NANS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WVO
Identifiers
Aliases	NANS, HEL-S-100, SAS, N-acetylneuraminate synthase, SEMDG, SEMDCG
External IDs	OMIM: 605202; MGI: 2149820; HomoloGene: 10343; GeneCards: NANS; OMA:NANS - orthologs
EC number	2.5.1.57
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 98,056,732 bp[1] End 98,083,077 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 46,489,248 bp[2] End 46,503,632 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon mucosa of transverse colon rectum epithelium of nasopharynx olfactory zone of nasal mucosa palpebral conjunctiva parotid gland prostate trachea bronchial epithelial cell Top expressed in left colon submandibular gland lacrimal gland seminal vesicula basilar part of occipital bone parotid gland crypt of lieberkuhn of small intestine prostate endothelial cell of lymphatic vessel internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function N-acetylneuraminate synthase activity transferase activity catalytic activity N-acylneuraminate cytidylyltransferase activity N-acylneuraminate-9-phosphate synthase activity Cellular component cytoplasm cytosol extracellular exosome Biological process carbohydrate biosynthetic process CMP-N-acetylneuraminate biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54187 94181 Ensembl ENSG00000095380 ENSMUSG00000028334 UniProt Q9NR45 Q5TBR0 Q99J77 RefSeq (mRNA) NM_018946 NM_053179 RefSeq (protein) NP_061819 NP_444409 Location (UCSC) Chr 9: 98.06 – 98.08 Mb Chr 4: 46.49 – 46.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. However, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.^[6]