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NAP1L4

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

NAP1L4
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Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.[5][6]

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This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.[6]

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