NAPG

Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.^[5][6]

NAPG
Identifiers
Aliases	NAPG, GAMMASNAP, NSF attachment protein gamma
External IDs	OMIM: 603216; MGI: 104561; HomoloGene: 2838; GeneCards: NAPG; OMA:NAPG - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.22 Start 10,525,905 bp[1] End 10,552,764 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 63,110,902 bp[2] End 63,132,521 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pons pars compacta Brodmann area 23 islet of Langerhans C1 segment lateral nuclear group of thalamus middle temporal gyrus dorsolateral prefrontal cortex Brodmann area 9 Top expressed in subiculum pontine nuclei piriform cortex central gray substance of midbrain medial dorsal nucleus primary motor cortex inferior colliculi subdivision of hippocampus Region I of hippocampus proper habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin binding protein binding soluble NSF attachment protein activity Cellular component myelin sheath lysosomal membrane SNARE complex extracellular exosome membrane mitochondrion vacuolar membrane synapse Biological process protein transport protein stabilization membrane fusion intracellular protein transport intra-Golgi vesicle-mediated transport vesicle-mediated transport transport protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8774 108123 Ensembl ENSG00000134265 ENSMUSG00000024581 UniProt Q99747 Q9CWZ7 RefSeq (mRNA) NM_003826 NM_028017 RefSeq (protein) NP_003817 NP_082293 Location (UCSC) Chr 18: 10.53 – 10.55 Mb Chr 18: 63.11 – 63.13 Mb PubMed search [3] [4]
Wikidata
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Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.^[6]