NAT10

N-acetyltransferase 10 is an enzyme that in humans is encoded by the NAT10 gene.^[5][6] NAT10 moderates the formation of N4-acetylcytidine RNA modifications on tRNA, rRNA, and mRNA.^[7][8][9]

NAT10
Identifiers
Aliases	NAT10, ALP, NET43, N-acetyltransferase 10, Kre33
External IDs	OMIM: 609221; MGI: 2138939; HomoloGene: 6785; GeneCards: NAT10; OMA:NAT10 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 34,105,617 bp[1] End 34,147,670 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E2 Start 103,551,601 bp[2] End 103,591,615 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve skin of leg skin of abdomen ventricular zone right ovary left ovary Achilles tendon body of pancreas tonsil right uterine tube Top expressed in spermatocyte epiblast neural layer of retina yolk sac primitive streak spermatid tail of embryo Paneth cell lens ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding acyltransferase activity protein binding ATP binding N-acetyltransferase activity tRNA binding tRNA N-acetyltransferase activity rRNA cytidine N-acetyltransferase activity RNA binding DNA polymerase binding Cellular component nucleolus membrane nucleus telomerase holoenzyme complex nucleoplasm midbody 90S preribosome Biological process rRNA processing negative regulation of telomere maintenance via telomerase tRNA processing ncRNA processing rRNA metabolic process rRNA modification tRNA wobble cytosine modification tRNA acetylation rRNA acetylation involved in maturation of SSU-rRNA ribosomal small subunit biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55226 98956 Ensembl ENSG00000135372 ENSMUSG00000027185 UniProt Q9H0A0 Q8K224 RefSeq (mRNA) NM_001144030 NM_024662 NM_153126 RefSeq (protein) NP_001137502 NP_078938 NP_694766 Location (UCSC) Chr 11: 34.11 – 34.15 Mb Chr 2: 103.55 – 103.59 Mb PubMed search [3] [4]
Wikidata
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