NCAPG2

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.^[5][6] CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis^[7]

NCAPG2
Identifiers
Aliases	NCAPG2, CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2, non-SMC condensin II complex subunit G2, 3KS
External IDs	OMIM: 608532; MGI: 1923294; HomoloGene: 9820; GeneCards: NCAPG2; OMA:NCAPG2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 158,631,169 bp[1] End 158,704,804 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F2 Start 116,369,022 bp[2] End 116,427,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone secondary oocyte sperm ganglionic eminence bone marrow bone marrow cell trabecular bone stromal cell of endometrium gonad right testis Top expressed in nasal epithelium olfactory epithelium secondary oocyte primary oocyte zygote ventricular zone fetal liver hematopoietic progenitor cell tail of embryo dermis superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methylated histone binding protein binding bHLH transcription factor binding molecular function regulator Cellular component membrane nucleus nucleoplasm condensin complex nuclear speck Biological process cell division cell cycle chromosome condensation inner cell mass cell proliferation transcription by RNA polymerase II erythrocyte differentiation negative regulation of erythrocyte differentiation positive regulation of protein tyrosine kinase activity positive regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54892 76044 Ensembl ENSG00000146918 ENSMUSG00000042029 UniProt Q86XI2 Q6DFV1 RefSeq (mRNA) NM_001281932 NM_001281933 NM_017760 NM_133762 RefSeq (protein) NP_001268861 NP_001268862 NP_060230 NP_598523 Location (UCSC) Chr 7: 158.63 – 158.7 Mb Chr 12: 116.37 – 116.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical importance

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.^[8]