NCKIPSD

NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.^[4][5][6]

NCKIPSD
Identifiers
Aliases	NCKIPSD, AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH, NCK interacting protein with SH3 domain
External IDs	OMIM: 606671; MGI: 1931834; HomoloGene: 9514; GeneCards: NCKIPSD; OMA:NCKIPSD - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,673,844 bp[1] End 48,686,364 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex middle temporal gyrus primary visual cortex Brodmann area 9 right hemisphere of cerebellum Brodmann area 23 right auricle of heart anterior cingulate cortex superior frontal gyrus n/a More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding cytoskeletal protein binding protein binding Cellular component COP9 signalosome cytosol intermediate filament nucleus Biological process cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis signal transduction NLS-bearing protein import into nucleus positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51517 80987 Ensembl ENSG00000213672 ENSMUSG00000032598 UniProt Q9NZQ3 Q9ESJ4 RefSeq (mRNA) NM_184231 NM_016453 NM_030729 RefSeq (protein) NP_057537 NP_909119 NP_109654 Location (UCSC) Chr 3: 48.67 – 48.69 Mb n/a PubMed search [2] [3]
Wikidata
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The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.^[6]

Interactions

NCKIPSD has been shown to interact with Grb2^[7][8] and NCK1.^[9]