NCOA4

Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene.^[5][6][7] It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.

NCOA4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1T5Z
Identifiers
Aliases	NCOA4, ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
External IDs	OMIM: 601984; MGI: 1350932; HomoloGene: 38052; GeneCards: NCOA4; OMA:NCOA4 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.22 Start 46,005,088 bp[1] End 46,030,623 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 31,881,822 bp[2] End 31,901,812 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa trabecular bone visceral pleura parietal pleura epithelium of nasopharynx palpebral conjunctiva gingival epithelium tibia kidney tubule Epithelium of choroid plexus Top expressed in spermatid spermatocyte zygote secondary oocyte granulocyte duodenum primary oocyte bone marrow liver uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function androgen receptor binding transcription coactivator activity Cellular component nucleus autolysosome Biological process androgen receptor signaling pathway positive regulation of transcription, DNA-templated male gonad development transcription, DNA-templated regulation of transcription, DNA-templated protein targeting to lysosome cellular iron ion homeostasis response to hormone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8031 27057 Ensembl ENSG00000266412 ENSMUSG00000056234 UniProt Q13772 n/a RefSeq (mRNA) NM_005437 NM_001145260 NM_001145261 NM_001145262 NM_001145263 NM_001033988 NM_001284319 NM_019744 RefSeq (protein) NP_001138732 NP_001138733 NP_001138734 NP_001138735 NP_005428 n/a Location (UCSC) Chr 10: 46.01 – 46.03 Mb Chr 14: 31.88 – 31.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

NCOA4 has been shown to interact with:

• Androgen receptor,^{[6][8][9][10][11][12][13][14][15]} and
• Peroxisome proliferator-activated receptor gamma^[16]
• Ferritin^[17][18]
• ATG8^[19]

See also

• Transcription coregulator