NCOA5

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.^[4][5]

NCOA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V95, 2J7Y, 4ZI1
Identifiers
Aliases	NCOA5, CIA, bA465L10.6, nuclear receptor coactivator 5
External IDs	OMIM: 616825; MGI: 2385165; HomoloGene: 32496; GeneCards: NCOA5; OMA:NCOA5 - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2|2 H3 Start 164,842,277 bp[1] End 164,876,787 bp[1]
Gene ontology Molecular function protein binding chromatin binding RNA binding Cellular component nucleus actin cytoskeleton extracellular space Biological process negative regulation of insulin receptor signaling pathway regulation of transcription, DNA-templated glucose homeostasis transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57727 228869 Ensembl ENSG00000124160 ENSMUSG00000039804 UniProt Q9HCD5 Q5JY17 Q91W39 RefSeq (mRNA) NM_020967 NM_144892 RefSeq (protein) NP_066018 NP_001335077 NP_001335078 NP_001335079 NP_001335080 NP_659141 Location (UCSC) n/a Chr 2: 164.84 – 164.88 Mb PubMed search [2] [3]
Wikidata
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Function

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.^[4]