NDUFAF8

NADH:ubiquinone oxidoreductase complex assembly factor 8 is a protein that in humans is encoded by the NDUFAF8 gene.^[4] This protein stabilizes NDUFAF5 during assembly of mitochondrial Complex I.^[5]

NDUFAF8
Identifiers
Aliases	NDUFAF8, C17orf89, NADH:ubiquinone oxidoreductase complex assembly factor 8
External IDs	OMIM: 618461; MGI: 1913676; HomoloGene: 83602; GeneCards: NDUFAF8; OMA:NDUFAF8 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11|11 E2 Start 119,989,754 bp[1] End 119,991,531 bp[1]
Gene ontology Molecular function protein binding Cellular component mitochondrion Biological process mitochondrial respiratory chain complex I assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284184 208501 Ensembl ENSG00000224877 ENSMUSG00000078572 UniProt A1L188 A2AMZ4 RefSeq (mRNA) NM_001086521 NM_001110242 RefSeq (protein) NP_001079990 NP_001340331 NP_001340332 NP_001103712 Location (UCSC) n/a Chr 11: 119.99 – 119.99 Mb PubMed search [2] [3]
Wikidata
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Structure

The NDUFAF8 gene is located on the q arm of chromosome 17 in position 25.3 and spans 1,987 base pairs.^[4] The gene produces a 7.756 kDa protein composed of 74 amino acids.^[6][7]

Function

The protein encoded by the NDUFAF8 gene is involved in the assembly of mitochondrial Complex I (NADH-ubiquinone oxidoreductase). This protein is required to stabilize NDUFAF5 during assembly of Complex I.^[5]

Interaction

NDUFAF8 has protein-protein interactions with NDUFAF5, stabilizing it.^[5]