NEFM

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.^[5][6]

NEFM
Identifiers
Aliases	NEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium, neurofilament medium chain
External IDs	OMIM: 162250; MGI: 97314; HomoloGene: 38041; GeneCards: NEFM; OMA:NEFM - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 24,913,758 bp[1] End 24,919,098 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 68,320,039 bp[2] End 68,362,295 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia lateral nuclear group of thalamus pons middle temporal gyrus Brodmann area 23 endothelial cell superior vestibular nucleus pars compacta primary visual cortex frontal pole Top expressed in anterior horn of spinal cord superior cervical ganglion deep cerebellar nuclei facial motor nucleus trigeminal ganglion pontine nuclei medial vestibular nucleus dorsal tegmental nucleus motor neuron lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding structural constituent of cytoskeleton protein binding structural molecule activity Cellular component neurofibrillary tangle axon intermediate filament neurofilament intermediate filament cytoskeleton Biological process neurofilament bundle assembly axon development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4741 18040 Ensembl ENSG00000104722 ENSMUSG00000022054 UniProt P07197 P08553 RefSeq (mRNA) NM_005382 NM_001105541 NM_008691 RefSeq (protein) NP_001099011 NP_005373 NP_032717 Location (UCSC) Chr 8: 24.91 – 24.92 Mb Chr 14: 68.32 – 68.36 Mb PubMed search [3] [4]
Wikidata
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Function

Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the exoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.^[6]