NEGR1

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.^[5]

NEGR1
Identifiers
Aliases	NEGR1, DMML2433, IGLON4, KILON, Ntra, neuronal growth regulator 1
External IDs	OMIM: 613173; MGI: 2444846; HomoloGene: 41447; GeneCards: NEGR1; OMA:NEGR1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 71,395,943 bp[1] End 72,282,539 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H4 Start 156,267,431 bp[2] End 157,022,082 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 Brodmann area 23 occipital lobe primary visual cortex superior frontal gyrus spinal ganglia superficial temporal artery parietal lobe middle temporal gyrus Achilles tendon Top expressed in piriform cortex anterior amygdaloid area cerebellar vermis subiculum lobe of cerebellum ventromedial nucleus olfactory tubercle inferior colliculi lateral hypothalamus nucleus accumbens More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component anchored component of membrane membrane extracellular region plasma membrane Biological process cell adhesion locomotory behavior feeding behavior positive regulation of neuron projection development cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 257194 320840 Ensembl ENSG00000172260 ENSMUSG00000040037 UniProt Q7Z3B1 Q80Z24 RefSeq (mRNA) NM_173808 NM_001039094 NM_177274 RefSeq (protein) NP_776169 NP_001034183 NP_796248 Location (UCSC) Chr 1: 71.4 – 72.28 Mb Chr 3: 156.27 – 157.02 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Variants of the NEGR1 gene may be associated with obesity and major depression.^[6][7][8]