NEIL2

Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.^[4][5][6]

NEIL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VZP
Identifiers
Aliases	NEIL2, NEH2, NEI2, nei like DNA glycosylase 2
External IDs	OMIM: 608933; MGI: 2686058; HomoloGene: 17032; GeneCards: NEIL2; OMA:NEIL2 - orthologs
Gene location (Mouse) Chr. Chromosome 14 (mouse)[1] Band 14|14 D1 Start 63,419,892 bp[1] End 63,431,305 bp[1]
Gene ontology Molecular function DNA binding microtubule binding zinc ion binding hydrolase activity, hydrolyzing N-glycosyl compounds metal ion binding hydrolase activity, acting on glycosyl bonds damaged DNA binding protein binding catalytic activity lyase activity nucleic acid binding DNA-(apurinic or apyrimidinic site) endonuclease activity hydrolase activity DNA N-glycosylase activity class I DNA-(apurinic or apyrimidinic site) endonuclease activity Cellular component cytoplasm microtubule cytoskeleton spindle microtubule nucleus nucleoplasm intracellular membrane-bounded organelle Biological process nucleotide-excision repair cellular response to DNA damage stimulus depyrimidination metabolism base-excision repair DNA repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 252969 382913 Ensembl ENSG00000154328 ENSMUSG00000035121 UniProt Q969S2 Q6R2P8 RefSeq (mRNA) NM_001135746 NM_001135747 NM_001135748 NM_145043 NM_201610 RefSeq (protein) NP_001129218 NP_001129219 NP_001129220 NP_659480 NP_001336368 NP_001336369 NP_001336370 NP_001336371 NP_963904 Location (UCSC) n/a Chr 14: 63.42 – 63.43 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM]^[6]

See also

• NEIL1
• NEIL3
• OGG1
• NTHL1