NEK3

Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene.^[5][6][7]

NEK3
Identifiers
Aliases	NEK3, HSPK36, NIMA related kinase 3
External IDs	OMIM: 604044; MGI: 1344371; HomoloGene: 1869; GeneCards: NEK3; OMA:NEK3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.3 Start 52,132,639 bp[1] End 52,159,861 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 11.07 cM Start 22,618,299 bp[2] End 22,656,451 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gonad mucosa of transverse colon testicle right testis left testis C1 segment rectum corpus callosum Achilles tendon Top expressed in fossa medullary collecting duct trigeminal ganglion facial motor nucleus superior cervical ganglion urothelium condyle renal corpuscle transitional epithelium of urinary bladder lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATP binding protein kinase activity protein binding kinase activity metal ion binding nucleotide binding transferase activity protein serine/threonine kinase activity Cellular component cell projection axon nucleus cytoplasm Biological process establishment of cell polarity cell cycle phosphorylation cell division neuron projection morphogenesis regulation of tubulin deacetylation protein phosphorylation mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4752 23954 Ensembl ENSG00000136098 ENSMUSG00000031478 UniProt P51956 Q9R0A5 RefSeq (mRNA) NM_001146099 NM_002498 NM_152720 NM_001162947 NM_011848 RefSeq (protein) NP_001139571 NP_002489 NP_689933 NP_001156419 NP_035978 Location (UCSC) Chr 13: 52.13 – 52.16 Mb Chr 8: 22.62 – 22.66 Mb PubMed search [3] [4]
Wikidata
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In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.^[7]