NEK8

Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.^[5][6]

NEK8
Identifiers
Aliases	NEK8, JCK, NEK12A, NPHP9, RHPD2, NIMA related kinase 8
External IDs	OMIM: 609799; MGI: 1890646; HomoloGene: 84442; GeneCards: NEK8; OMA:NEK8 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,725,897 bp[1] End 28,743,455 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,056,932 bp[2] End 78,067,501 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell left lobe of thyroid gland granulocyte right lobe of thyroid gland right uterine tube lymph node right adrenal cortex monocyte visceral pleura testicle Top expressed in saccule otic vesicle lumbar spinal ganglion spermatocyte tail of embryo right kidney genital tubercle proximal tubule ventricular zone granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity nucleotide binding protein kinase activity protein binding ATP binding metal ion binding protein serine/threonine kinase activity Cellular component cytoplasm ciliary base cell projection cytoskeleton ciliary inversin compartment cilium Biological process animal organ morphogenesis heart development regulation of hippo signaling determination of left/right symmetry phosphorylation protein phosphorylation cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284086 140859 Ensembl ENSG00000160602 ENSMUSG00000017405 UniProt Q86SG6 Q91ZR4 RefSeq (mRNA) NM_178170 NM_080849 RefSeq (protein) NP_835464 NP_543125 Location (UCSC) Chr 17: 28.73 – 28.74 Mb Chr 11: 78.06 – 78.07 Mb PubMed search [3] [4]
Wikidata
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Function

Nek8 is a member of the serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase.^[5]

Clinical significance

Mutations in the NEK8 gene associated with nephronophthisis.^[7][8]