NELL1

Protein kinase C-binding protein NELL1 also known as NEL-like protein 1 (NELL1) or Nel-related protein 1 (NRP1) is a protein that in humans is encoded by the NELL1 gene.^[5][6][7]

NELL1
Identifiers
Aliases	NELL1, IDH3GL, NRP1, neural EGFL like 1
External IDs	OMIM: 602319; MGI: 2443902; HomoloGene: 4486; GeneCards: NELL1; OMA:NELL1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.1 Start 20,669,551 bp[1] End 21,575,686 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B4 Start 49,624,612 bp[2] End 50,516,356 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell buccal mucosa cell ventricular zone orbitofrontal cortex Brodmann area 46 middle temporal gyrus prefrontal cortex sperm Brodmann area 10 superior frontal gyrus Top expressed in medial geniculate nucleus medial dorsal nucleus lateral geniculate nucleus dorsomedial hypothalamic nucleus facial motor nucleus suprachiasmatic nucleus superior colliculus ventral tegmental area paraventricular nucleus of hypothalamus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding protein kinase C binding heparin binding Cellular component cytoplasm perinuclear region of cytoplasm extracellular region nuclear envelope nucleus Biological process regulation of gene expression negative regulation of osteoblast proliferation cell differentiation positive regulation of osteoblast differentiation nervous system development positive regulation of bone mineralization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4745 338352 Ensembl ENSG00000165973 ENSMUSG00000055409 UniProt Q92832 Q2VWQ2 RefSeq (mRNA) NM_001288713 NM_001288714 NM_006157 NM_201551 NM_001037906 NM_177413 RefSeq (protein) NP_001275642 NP_001275643 NP_006148 NP_963845 NP_001032995 Location (UCSC) Chr 11: 20.67 – 21.58 Mb Chr 7: 49.62 – 50.52 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full-length sequence has not been determined.^[6]

Recent study by UCLA researchers shows that administering the protein NELL-1 intravenously stimulates significant bone formation through the regenerative ability of stem cells.^[7]