NEO1

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[5][6]

NEO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2
Identifiers
Aliases	NEO1, IGDCC2, NGN, NTN1R2, neogenin 1
External IDs	OMIM: 601907; MGI: 1097159; HomoloGene: 1870; GeneCards: NEO1; OMA:NEO1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 73,051,710 bp[1] End 73,305,205 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 58,781,970 bp[2] End 58,943,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone internal globus pallidus inferior ganglion of vagus nerve rectum epithelium of colon subthalamic nucleus corpus callosum ventral tegmental area superior vestibular nucleus pylorus Top expressed in external carotid artery internal carotid artery epithelium of lens renal corpuscle medullary collecting duct substantia nigra ciliary body ascending aorta Rostral migratory stream aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-receptor binding protein binding signaling receptor activity Cellular component integral component of membrane plasma membrane protein complex plasma membrane Golgi apparatus integral component of plasma membrane membrane nucleoplasm Biological process positive regulation of BMP signaling pathway iron ion homeostasis cell adhesion nervous system development axon guidance signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4756 18007 Ensembl ENSG00000067141 ENSMUSG00000032340 UniProt Q92859 P97798 RefSeq (mRNA) NM_001172623 NM_001172624 NM_002499 NM_001042752 NM_008684 RefSeq (protein) NP_001166094 NP_001166095 NP_002490 n/a Location (UCSC) Chr 15: 73.05 – 73.31 Mb Chr 9: 58.78 – 58.94 Mb PubMed search [3] [4]
Wikidata
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Interactions

NEO1 has been shown to interact with PTK2.^[7] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. ^[8]