NEURL2

Neuralized-like protein 2 is a protein that in humans is encoded by the NEURL2 gene.^[5][6]

NEURL2
Identifiers
Aliases	NEURL2, C20orf163, OZZ, OZZ-E3, neuralized E3 ubiquitin protein ligase 2
External IDs	OMIM: 608597; MGI: 3043305; HomoloGene: 15435; GeneCards: NEURL2; OMA:NEURL2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,888,625 bp[1] End 45,891,208 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,672,652 bp[2] End 164,675,376 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle apex of heart gastric mucosa gonad muscle of thigh tendon of biceps brachii thymus gastrocnemius muscle right adrenal cortex quadriceps femoris muscle Top expressed in interventricular septum vastus lateralis muscle triceps brachii muscle temporal muscle myocardium of ventricle ankle muscle of thigh sternocleidomastoid muscle medial head of gastrocnemius muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin protein ligase activity Cellular component cytoplasm cytosol Biological process intracellular signal transduction protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140825 415115 Ensembl ENSG00000124257 ENSMUSG00000039873 UniProt Q9BR09 Q9D0S4 RefSeq (mRNA) NM_080749 NM_001278535 NM_001082974 RefSeq (protein) NP_001265464 NP_542787 NP_001076443 Location (UCSC) Chr 20: 45.89 – 45.89 Mb Chr 2: 164.67 – 164.68 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.^[6]

See also

• NEURL (gene)