NFATC3

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.^[5][6]

NFATC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XRW, 2XS0
Identifiers
Aliases	NFATC3, NFAT4, NFATX, nuclear factor of activated T-cells 3, nuclear factor of activated T cells 3, NF-AT4c
External IDs	OMIM: 602698; MGI: 103296; HomoloGene: 27827; GeneCards: NFATC3; OMA:NFATC3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 68,084,751 bp[1] End 68,229,259 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.08 cM Start 106,785,472 bp[2] End 106,857,169 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte bone marrow cell epithelium of colon sperm thymus gastrocnemius muscle granulocyte muscle of thigh right testis Top expressed in thymus tail of embryo blood genital tubercle fossa condyle spleen Gonadal ridge dermis renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding transcription factor binding Cellular component cytoplasm nucleoplasm nucleus cytosol transcription regulator complex Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated Fc-epsilon receptor signaling pathway inflammatory response positive regulation of transcription by RNA polymerase II negative regulation of pri-miRNA transcription by RNA polymerase II negative regulation of vascular associated smooth muscle cell differentiation cytokine production calcineurin-NFAT signaling cascade multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4775 18021 Ensembl ENSG00000072736 ENSMUSG00000031902 UniProt Q12968 P97305 RefSeq (mRNA) NM_173165 NM_004555 NM_173163 NM_173164 NM_010901 NM_001368796 NM_001368797 RefSeq (protein) NP_004546 NP_775186 NP_775188 NP_004546.1 NP_775188.1 n/a Location (UCSC) Chr 16: 68.08 – 68.23 Mb Chr 8: 106.79 – 106.86 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.^[6]

See also

• NFAT